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Molecules 2016, 21(6), 819; doi:10.3390/molecules21060819

Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea

1
Center for Biodiversity and Drug Discovery, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge 0843-01103, Panama
2
Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, India
3
Center for Molecular and Cellular Biology of Diseases, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge 0843-01103, Panama
4
Smithsonian Tropical Research Institute, Balboa, Ancon 0843-03092, Panama
5
Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Salamanca, Ave. Campo Charro, s/n, Salamanca 37007, Spain
6
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and The Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92037, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Quan-Bin Han
Received: 11 May 2016 / Revised: 17 June 2016 / Accepted: 18 June 2016 / Published: 22 June 2016
(This article belongs to the Special Issue Diterpene and Its Significance in Natural Medicine)
View Full-Text   |   Download PDF [1507 KB, uploaded 22 June 2016]   |  

Abstract

Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH2Cl2-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama. Their structures were determined using spectroscopic analyses, including 1D and 2D NMR and high-resolution mass spectrometry (HRMS) together with molecular modeling studies. Compounds 13 displayed anti-inflammatory properties by inhibiting production of Tumor Necrosis Factor (TNF) and Interleukin (IL)-6 induced by lipopolysaccharide (LPS) in murine macrophages. View Full-Text
Keywords: Eunicea succinea; cembranolide diterpenes; uprolides; anti-inflammatory Eunicea succinea; cembranolide diterpenes; uprolides; anti-inflammatory
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MDPI and ACS Style

Torres-Mendoza, D.; González, Y.; Gómez-Reyes, J.F.; Guzmán, H.M.; López-Perez, J.L.; Gerwick, W.H.; Fernandez, P.L.; Gutiérrez, M. Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea. Molecules 2016, 21, 819.

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