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Molecules 2016, 21(6), 815; doi:10.3390/molecules21060815

Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions

Department of Chemistry, University of Malta, Msida MSD 2080, Malta
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Author to whom correspondence should be addressed.
Academic Editor: Alessandro Palmieri
Received: 20 May 2016 / Revised: 10 June 2016 / Accepted: 16 June 2016 / Published: 22 June 2016
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Abstract

Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs. View Full-Text
Keywords: Aza-Michael reactions; mono-addition; acidic alumina; solvent-free; primary amines Aza-Michael reactions; mono-addition; acidic alumina; solvent-free; primary amines
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Bosica, G.; Abdilla, R. Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions. Molecules 2016, 21, 815.

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