A New One-Pot Synthesis of Quinoline-2-carboxylates under Heterogeneous Conditions
AbstractQuinoline-2-carboxylates are an important subclass of quinoline derivatives largely present in a variety of biologically active molecules, as well as useful ligands in metal-catalyzed reactions. Herein, we present a new one-pot protocol for synthesizing this class of derivatives starting from β-nitroacrylates and 2-aminobenzaldehydes. In order to optimize the protocol, we investigated several reaction conditions, obtaining the best results using the 2-tert-Butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine (BEMP) as solid base, in acetonitrile. Finally, we demonstrated the generality of our approach over several substrates which led to synthesize a plethora of functionalized quinolines-2-carboxylate derivatives in good overall yields. View Full-Text
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Gabrielli, S.; Giardinieri, A.; Sampaolesi, S.; Ballini, R.; Palmieri, A. A New One-Pot Synthesis of Quinoline-2-carboxylates under Heterogeneous Conditions. Molecules 2016, 21, 776.
Gabrielli S, Giardinieri A, Sampaolesi S, Ballini R, Palmieri A. A New One-Pot Synthesis of Quinoline-2-carboxylates under Heterogeneous Conditions. Molecules. 2016; 21(6):776.Chicago/Turabian Style
Gabrielli, Serena; Giardinieri, Alessandra; Sampaolesi, Susanna; Ballini, Roberto; Palmieri, Alessandro. 2016. "A New One-Pot Synthesis of Quinoline-2-carboxylates under Heterogeneous Conditions." Molecules 21, no. 6: 776.
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