Next Article in Journal
Liquid Crystal Formation from Sunflower Oil: Long Term Stability Studies
Next Article in Special Issue
An Ingenol Derived from Euphorbia kansui Induces Hepatocyte Cytotoxicity by Triggering G0/G1 Cell Cycle Arrest and Regulating the Mitochondrial Apoptosis Pathway in Vitro
Previous Article in Journal
Synthesis of C2-Symmetric Benzimidazolium Salts and Their Application in Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides
Previous Article in Special Issue
Antimicrobial Diterpenoids of Wedelia trilobata (L.) Hitchc
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessCommunication
Molecules 2016, 21(6), 749; doi:10.3390/molecules21060749

Cytotoxic Labdane Diterpenes from Hedychium ellipticum Buch.-Ham. ex Sm.

Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
*
Author to whom correspondence should be addressed.
Academic Editors: Quan-Bin Han and Jian-Xin Pu
Received: 11 May 2016 / Revised: 27 May 2016 / Accepted: 3 June 2016 / Published: 9 June 2016
(This article belongs to the Special Issue Diterpene and Its Significance in Natural Medicine)
View Full-Text   |   Download PDF [363 KB, uploaded 9 June 2016]   |  

Abstract

In order to reveal the constituents and their biological activities, we carried out a phytochemical study on Hedychium ellipticum Buch.-Ham. ex Sm. (Zingiberaceae). Ten labdane diterpenoids (110) were isolated from the rhizomes of H. ellipticum for the first time. Their structures were identified on the basis of spectroscopic analyses including two-dimensional NMR and comparison with literature data. All of these compounds were evaluated for their antimycobacterial activity against Mycobacterium tuberculosis and cytotoxicity against KB, MCF7, NCI-H187 and Vero cells. The result showed that compounds 1 and 7 exhibited moderate activity against Mycobacterium tuberculosis and compounds 4, 6 and 7 displayed remarkable cytotoxic activity. This is the first report on the presence of all compounds in H. ellipticum and the first time that their structure activity relationship has been discussed. View Full-Text
Keywords: Hedychium ellipticum; labdane-type diterpene; cytotoxic activity; antimycobacterial activity Hedychium ellipticum; labdane-type diterpene; cytotoxic activity; antimycobacterial activity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Songsri, S.; Nuntawong, N. Cytotoxic Labdane Diterpenes from Hedychium ellipticum Buch.-Ham. ex Sm.. Molecules 2016, 21, 749.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top