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Molecules 2016, 21(6), 749; doi:10.3390/molecules21060749

Cytotoxic Labdane Diterpenes from Hedychium ellipticum Buch.-Ham. ex Sm.

Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
Author to whom correspondence should be addressed.
Academic Editors: Quan-Bin Han and Jian-Xin Pu
Received: 11 May 2016 / Revised: 27 May 2016 / Accepted: 3 June 2016 / Published: 9 June 2016
(This article belongs to the Special Issue Diterpene and Its Significance in Natural Medicine)
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In order to reveal the constituents and their biological activities, we carried out a phytochemical study on Hedychium ellipticum Buch.-Ham. ex Sm. (Zingiberaceae). Ten labdane diterpenoids (110) were isolated from the rhizomes of H. ellipticum for the first time. Their structures were identified on the basis of spectroscopic analyses including two-dimensional NMR and comparison with literature data. All of these compounds were evaluated for their antimycobacterial activity against Mycobacterium tuberculosis and cytotoxicity against KB, MCF7, NCI-H187 and Vero cells. The result showed that compounds 1 and 7 exhibited moderate activity against Mycobacterium tuberculosis and compounds 4, 6 and 7 displayed remarkable cytotoxic activity. This is the first report on the presence of all compounds in H. ellipticum and the first time that their structure activity relationship has been discussed. View Full-Text
Keywords: Hedychium ellipticum; labdane-type diterpene; cytotoxic activity; antimycobacterial activity Hedychium ellipticum; labdane-type diterpene; cytotoxic activity; antimycobacterial activity

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Songsri, S.; Nuntawong, N. Cytotoxic Labdane Diterpenes from Hedychium ellipticum Buch.-Ham. ex Sm.. Molecules 2016, 21, 749.

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