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Molecules 2016, 21(6), 742; doi:10.3390/molecules21060742

Synthesis of C2-Symmetric Benzimidazolium Salts and Their Application in Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides

1
School of Medicine, Zhejiang University City College, No. 48, Huzhou Road, Hangzhou 310015, China
2
Individualized Medication Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, School of Medicine, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China
3
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Diego A. Alonso and Isidro M. Pastor
Received: 14 April 2016 / Revised: 26 May 2016 / Accepted: 1 June 2016 / Published: 8 June 2016
(This article belongs to the Special Issue Palladium Catalysts 2016)
View Full-Text   |   Download PDF [886 KB, uploaded 8 June 2016]   |  

Abstract

A series of C2-symmetric chiral benzimidazolium salts, the precursor of N-heterocyclic carbene ligands, were designed and synthesized from 1,2-dibromobenzene. In situ prepared corresponding carbenes were tested in the asymmetric palladium-catalyzed intramolecular α-arylation of amides, affording chiral diarylmethanols with high yields and moderate enantioselectivities. View Full-Text
Keywords: N-heterocyclic carbene; benzimidazolium; Pd-catalyzed; asymmetric intramolecular α-arylation N-heterocyclic carbene; benzimidazolium; Pd-catalyzed; asymmetric intramolecular α-arylation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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He, W.; Zhao, W.; Zhou, B.; Liu, H.; Li, X.; Li, L.; Li, J.; Shi, J. Synthesis of C2-Symmetric Benzimidazolium Salts and Their Application in Palladium-Catalyzed Enantioselective Intramolecular α-Arylation of Amides. Molecules 2016, 21, 742.

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