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Molecules 2016, 21(6), 739; doi:10.3390/molecules21060739

Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L.

1
Department of Biology and Pharmaceutical Botany, Medical University of Lodz, ul. Muszynskiego 1, Lodz 90–151, Poland
2
Department of Pharmaceutical Biochemistry, Wroclaw Medical University, ul. Borowska 211A, Wroclaw 50-556, Poland
3
Department of Biology and Pharmaceutical Botany, Wroclaw Medical University, ul. Borowska 211, Wroclaw 50-556, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 24 April 2016 / Revised: 24 May 2016 / Accepted: 1 June 2016 / Published: 14 June 2016
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Methanolic extracts from the aerial parts and roots of two Scutellaria species, S. alpina and S. altissima, and five polyphenols from these plants demonstrated a significant ability to inhibit the formation of advanced glycation end-products (AGE) in vitro. S. alpina, which is richer in polyphenolic compounds, had strong antiglycation properties. These extracts demonstrated also high activity in the FRAP (ferric-reducing antioxidant power), antiradical (DPPH) and lipid peroxidation inhibition assays. Among the pure compounds, baicalin was the strongest glycation inhibitor (90.4% inhibition at 100 μg/mL), followed by luteolin (85.4%). Two other flavone glycosides had about half of this activity. Verbascoside was similar to the reference drug aminoguanidine (71.2% and 75.9%, respectively). The strong correlation observed between AGE inhibition and total flavonoid content indicated that flavonoids contribute significantly to antiglycation properties. A positive correlation was also observed between antiglycative and antioxidant activities. The studied skullcap species can be considered as a potential source of therapeutic agents for hyperglycemia-related disorders. View Full-Text
Keywords: advanced glycation end products; flavonoids; antioxidants; Scutellaria alpina; Scutellaria altissima advanced glycation end products; flavonoids; antioxidants; Scutellaria alpina; Scutellaria altissima
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Grzegorczyk-Karolak, I.; Gołąb, K.; Gburek, J.; Wysokińska, H.; Matkowski, A. Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L.. Molecules 2016, 21, 739.

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