Aza-Henry Reactions on C-Alkyl Substituted Aldimines
AbstractThe reactivity of C-CH3 substituted N-protected aldimines in aza-Henry addition reactions was compared with that of the analogous trifluoromethylated compounds. C-Alkyl aldimines easily reacted with nitro alkanes under solvent-free conditions and in the absence of catalyst, despite being worse electrophiles than C-CF3 aldimines, they gave the aza-Henry addition only when ZrCl4 was added. The presence of a bulky group on the imine carbon deeply influenced the reactivity. View Full-Text
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Pelagalli, A.; Pellacani, L.; Scandozza, E.; Fioravanti, S. Aza-Henry Reactions on C-Alkyl Substituted Aldimines. Molecules 2016, 21, 723.
Pelagalli A, Pellacani L, Scandozza E, Fioravanti S. Aza-Henry Reactions on C-Alkyl Substituted Aldimines. Molecules. 2016; 21(6):723.Chicago/Turabian Style
Pelagalli, Alessia; Pellacani, Lucio; Scandozza, Elia; Fioravanti, Stefania. 2016. "Aza-Henry Reactions on C-Alkyl Substituted Aldimines." Molecules 21, no. 6: 723.
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