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Molecules 2016, 21(6), 726; doi:10.3390/molecules21060726

Polyphenols from Erythrina crista-galli: Structures, Molecular Docking and Phytoestrogenic Activity

1
Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt
2
Department of Biology, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg 69120, Germany
3
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
4
Department of Pharmacognosy, Faculty of Pharmacy, British University of Egypt (BUE), Cairo 11837, Egypt
5
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt
6
Department of Pharmacology, Faculty of Medicine, Umm Al Qura University, Makkah 21955, Saudi Arabia
*
Author to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Received: 30 March 2016 / Revised: 21 May 2016 / Accepted: 27 May 2016 / Published: 3 June 2016
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Abstract

Objectives: The current study aimed at exploring the secondary metabolites content of Erythrina crista-galli aqueous methanol extract and assessing its phytoestrogenic and cytoprotective activities. Methods: Isolation of the compounds was carried out using conventional chromatographic techniques. The structures of the isolated compounds were elucidated based on the UV, NMR spectral data along with their mass-spectrometric analyses. The phytoestrogenic activity was evaluated in-silico and in vitro using the Arabidopsis thaliana pER8: GUS reporter assay and the proliferation-enhancing activity of MCF-7 cells. Key findings: Phytochemical investigation of E. crista-galli aqueous methanol extract resulted in the isolation and identification of five flavonoids. The plant extract and its fractions showed significant estrogenic activities compared to controls. Conclusion: Five flavonoids were identified from E. crista-galli aqueous methanol extract. To the best of our knowledge, among these flavonoids, apigenin-7-O-rhamnosyl-6-C-glucoside was isolated for the first time from nature. Moreover, luteolin-6-C-glucoside was isolated for the first time from this plant. The plant revealed promising phytoestrogenic activities. This gives rationale to some of its pharmacological properties and suggests additional phytoestrogenic effects, which have not been reported yet. View Full-Text
Keywords: Erythrina crista-galli; polyphenols; molecular docking study; phytoestrogenic activity Erythrina crista-galli; polyphenols; molecular docking study; phytoestrogenic activity
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MDPI and ACS Style

Ashmawy, N.S.; Ashour, M.L.; Wink, M.; El-Shazly, M.; Chang, F.-R.; Swilam, N.; Abdel-Naim, A.B.; Ayoub, N. Polyphenols from Erythrina crista-galli: Structures, Molecular Docking and Phytoestrogenic Activity. Molecules 2016, 21, 726.

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