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Molecules 2016, 21(6), 708; doi:10.3390/molecules21060708

Antioxidative and Antidiabetic Effects of Natural Polyphenols and Isoflavones

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu, Kagawa 761-0395, Japan
Author to whom correspondence should be addressed.
Academic Editors: Maurizio Battino and José L. Quiles
Received: 2 May 2016 / Revised: 23 May 2016 / Accepted: 25 May 2016 / Published: 30 May 2016
(This article belongs to the Special Issue 20th Anniversary of Molecules—Recent Advances in Natural Products)
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Many polyphenols that contain more than two phenolic hydroxyl groups are natural antioxidants and can provide health benefits to humans. These polyphenols include, for example, oleuropein, hydroxytyrosol, catechin, chlorogenic acids, hesperidin, nobiletin, and isoflavones. These have been studied widely because of their strong radical-scavenging and antioxidative effects. These effects may contribute to the prevention of diseases, such as diabetes. Insulin secretion, insulin resistance, and homeostasis are important factors in the onset of diabetes, a disease that is associated with dysfunction of pancreatic β-cells. Oxidative stress is thought to contribute to this dysfunction and the effects of antioxidants on the pathogenesis of diabetes have, therefore, been investigated. Here, we summarize the antioxidative effects of polyphenols from the perspective of their radical-scavenging activities as well as their effects on signal transduction pathways. We also describe the preventative effects of polyphenols on diabetes by referring to recent studies including those reported by us. Appropriate analytical approaches for evaluating antioxidants in studies on the prevention of diabetes are comprehensively reviewed. View Full-Text
Keywords: diabetes; oxidative stress; oleuropein; hydroxytyrosol; catechin; chlorogenic acids; hesperidin; isoflavone; insulin secretion; glucose tolerance diabetes; oxidative stress; oleuropein; hydroxytyrosol; catechin; chlorogenic acids; hesperidin; isoflavone; insulin secretion; glucose tolerance

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Umeno, A.; Horie, M.; Murotomi, K.; Nakajima, Y.; Yoshida, Y. Antioxidative and Antidiabetic Effects of Natural Polyphenols and Isoflavones. Molecules 2016, 21, 708.

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