Next Article in Journal
Efficient Preparation of Streptochlorin from Marine Streptomyces sp. SYYLWHS-1-4 by Combination of Response Surface Methodology and High-Speed Counter-Current Chromatography
Next Article in Special Issue
Eriobotrya japonica Water Extract Characterization: An Inducer of Interferon-Gamma Production Mainly by the JAK-STAT Pathway
Previous Article in Journal
Enantiopure Trisubstituted Tetrahydrofurans with Appendage Diversity: Vinyl Sulfone- and Vinyl Sulfoxide-Modified Furans Derived from Carbohydrates as Synthons for Diversity Oriented Synthesis
Previous Article in Special Issue
A New Canthinone-Type Alkaloid Isolated from Ailanthus altissima Swingle
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessArticle
Molecules 2016, 21(6), 688; doi:10.3390/molecules21060688

Phenolic Profile and Antioxidant Potential of Leaves from Selected Cotoneaster Medik. Species

1
Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Lodz, 1 Muszynskiego, 90-151 Lodz, Poland
2
Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Science, Lodz University of Technology, 4/10 Stefanowskiego, 90-924 Lodz, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 29 April 2016 / Revised: 19 May 2016 / Accepted: 20 May 2016 / Published: 26 May 2016
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [2397 KB, uploaded 26 May 2016]   |  

Abstract

The antioxidant efficiency of 70% aqueous methanolic extracts from the leaves of twelve selected Cotoneaster Medik. species was evaluated using four complementary in vitro tests based on SET- (single electron transfer) and HAT-type (hydrogen atom transfer) mechanisms (DPPH, FRAP, O2•− and H2O2 scavenging assays). The samples exhibited the dose-dependent responses in all assays with activity parameters of EC50 = 18.5–34.5 µg/mL for DPPH; 0.9–3.8 mmol Fe2+/g for FRAP; SC50 = 27.7–74.8 µg/mL for O2•−; and SC50 = 29.0–91.3 µg/mL for H2O2. Significant linear correlations (|r| = 0.76–0.97, p < 0.01) between activity parameters and total contents of phenolics (5.2%–15.4% GAE) and proanthocyanidins (2.1%–15.0% CYE), with weak or no effects for chlorogenic acid isomers (0.69%–2.93%) and total flavonoids (0.28%–1.40%) suggested that among the listed polyphenols, proanthocyanidins are the most important determinants of the tested activity. UHPLC-PDA-ESI-QTOF-MS analyses led to detection of 34 polyphenols, of which 10 B-type procyanidins, 5 caffeoylquinic acids and 14 flavonoids were identified. After cluster analysis of the data matrix, the leaves of Cotoneaster zabelii, C. splendens, C. bullatus, C. divaricatus, C. hjelmqvistii and C. lucidus were selected as the most promising sources of natural antioxidants, exhibiting the highest phenolic levels and antioxidant capacities, and therefore the greatest potential for pharmaceutical applications. View Full-Text
Keywords: Cotoneaster; antioxidant activity; UHPLC-PDA-ESI-QTOF-MS; HPLC-PDA; phenolic profile; phenolic, proanthocyanidin, chlorogenic acid isomer and flavonoid contents Cotoneaster; antioxidant activity; UHPLC-PDA-ESI-QTOF-MS; HPLC-PDA; phenolic profile; phenolic, proanthocyanidin, chlorogenic acid isomer and flavonoid contents
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kicel, A.; Michel, P.; Owczarek, A.; Marchelak, A.; Żyżelewicz, D.; Budryn, G.; Oracz, J.; Olszewska, M.A. Phenolic Profile and Antioxidant Potential of Leaves from Selected Cotoneaster Medik. Species. Molecules 2016, 21, 688.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top