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Molecules 2016, 21(6), 686; doi:10.3390/molecules21060686

Dendrimer Prodrugs

Laboratory of Design and Synthesis of Chemotherapeutics Potentially Active in Neglected Diseases (LAPEN), Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo—USP, Avenue Professor Lineu Prestes, 580–Building 13, São Paulo SP, 05508-900, Brazil
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Academic Editor: Ashok Kakkar
Received: 7 April 2016 / Revised: 10 May 2016 / Accepted: 17 May 2016 / Published: 31 May 2016
(This article belongs to the Special Issue Functional Dendrimers)

Abstract

The main objective of this review is to describe the importance of dendrimer prodrugs in the design of new drugs, presenting numerous applications of these nanocomposites in the pharmaceutical field. Therefore, the use of dendrimer prodrugs as carrier for drug delivery, to improve pharmacokinetic properties of prototype, to promote drug sustained-release, to increase selectivity and, consequently, to decrease toxicity, are just some examples of topics that have been extensively reported in the literature, especially in the last decade. The examples discussed here give a panel of the growing interest dendrimer prodrugs have been evoking in the scientific community. View Full-Text
Keywords: dendrimer; prodrugs; molecular modifications; targeted dendrimer; pharmaceutical applications dendrimer; prodrugs; molecular modifications; targeted dendrimer; pharmaceutical applications
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

da Silva Santos, S.; Igne Ferreira, E.; Giarolla, J. Dendrimer Prodrugs. Molecules 2016, 21, 686.

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