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Molecules 2016, 21(5), 679; doi:10.3390/molecules21050679

New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp.

Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara-cho, Okinawa 903-2013, Japan
Department of Bioresources Engineering, Okinawa National College of Technology, 905 Henoko, Nago-shi, Okinawa 905-2192, Japan
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 16 April 2016 / Revised: 18 May 2016 / Accepted: 18 May 2016 / Published: 23 May 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1594 KB, uploaded 24 May 2016]   |  


A new rare casbane-type diterpenoid 1 and two new cembrane diterpenoids 2, 3 were isolated from an Okinawan soft coral, Lobophytum sp., together with four known cembrane diterpenoids 4–7. Their structures were elucidated by extensive analysis of spectroscopic data (1D and 2D NMR, IR, and MS) and a molecular modeling study. The new isolates showed weak anti-bacterial activity, mild cytotoxicity against HCT116 cells, and anti-inflammatory effect in LPS/IFN-γ-stimulated RAW 264.7 macrophage cells. View Full-Text
Keywords: casbane; cembrane; antibacterial; cytotoxicity; HCT 116 cells; anti-inflammatory casbane; cembrane; antibacterial; cytotoxicity; HCT 116 cells; anti-inflammatory

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Roy, P.K.; Ashimine, R.; Miyazato, H.; Taira, J.; Ueda, K. New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp.. Molecules 2016, 21, 679.

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