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Molecules 2016, 21(5), 651; doi:10.3390/molecules21050651

Taxanes in the Treatment of Advanced Gastric Cancer

1
Department of Oncology/Hematology, Kyungpook National University Medical Center, Kyungpook National University School of Medicine, Kyungpook National University Cancer Research Institute, 807 Hogukno, buk-gu, Daegu 41404, Korea
2
Department of Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 41494, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Iwao Ojima
Received: 12 April 2016 / Revised: 12 May 2016 / Accepted: 13 May 2016 / Published: 17 May 2016
(This article belongs to the Special Issue New Generation of Microtubule-Interacting Anticancer Agents)
View Full-Text   |   Download PDF [1382 KB, uploaded 17 May 2016]

Abstract

Although rapid advances in treatment options have improved the prognosis of advanced gastric cancer (AGC), it remains a major public health problem and the second leading cause of cancer-related deaths in the world. Taxanes (paclitaxel and docetaxel) are microtubule stabilizing agents that inhibit the process of cell division, and have shown antitumor activity in the treatment of AGC as a single or combination chemotherapy. Accordingly, this review focuses on the efficacy and tolerability of taxanes in the first- or second-line chemotherapy setting for AGC. View Full-Text
Keywords: gastric cancer; taxanes; paclitaxel; docetaxel; chemotherapy gastric cancer; taxanes; paclitaxel; docetaxel; chemotherapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kang, B.W.; Kwon, O.-K.; Chung, H.Y.; Yu, W.; Kim, J.G. Taxanes in the Treatment of Advanced Gastric Cancer. Molecules 2016, 21, 651.

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