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Molecules 2016, 21(4), 490; doi:10.3390/molecules21040490

Sesquiterpenoids and Diterpenoids from the Wood of Cunninghamia konishii and Their Inhibitory Activities against NO Production

1
Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
2
Department of Biotechnology, Hungkuang University, Taichung 443, Taiwan
3
Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan
4
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
5
Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan
6
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
7
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
8
Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
9
School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
10
Department of Chemistry, National Taiwan University, Taipei 106, Taiwan
11
Department of Biotechnology, Asia University, Taichung 413, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 19 March 2016 / Revised: 6 April 2016 / Accepted: 7 April 2016 / Published: 13 April 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [542 KB, uploaded 13 April 2016]   |  

Abstract

Three new sesquiterpenoids, 2α-hydroxy-3,3,6α,9β-tetramethyltricyclo[4,3,21,4]undecane (1), 11-acetoxyeudesman-4β-ol (4), and 2α,3β-dihydroxy-4β-methyl-6,8,10-cadinatriene (6), four known sesquiterpenoids (2, 3, 5, and 7), together with eight known diterpenoids (8–15), were isolated from the wood of Cunninghamia konishii. Their structures were determined by detailed analysis of spectroscopic data and comparison with the data of known analogues. Four sesquiterpenoids (1, 4, 5, and 6) and all the diterpenoids (8–15) were evaluated for inhibition of nitric oxide production in lipopolysaccharides (LPS)-activated RAW 264.7 macrophages and the results showed that compounds 10 and 15 exhibited moderate inhibitory activities against nitric oxide production. View Full-Text
Keywords: Chinese herb; Taxodiaceae; Cunninghamia konishii; eudesmane; cadinane; sesquiterpenoid Chinese herb; Taxodiaceae; Cunninghamia konishii; eudesmane; cadinane; sesquiterpenoid
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MDPI and ACS Style

Chang, C.-I.; Chen, C.-C.; Chao, C.-Y.; Wang, S.-Y.; Chang, H.-S.; Sung, P.-J.; Huang, G.-J.; Li, Y.-C.; Kuo, Y.-H. Sesquiterpenoids and Diterpenoids from the Wood of Cunninghamia konishii and Their Inhibitory Activities against NO Production. Molecules 2016, 21, 490.

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