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Molecules 2016, 21(4), 441; doi:10.3390/molecules21040441

A Novel and Efficient Five-Component Synthesis of Pyrazole Based Pyrido[2,3-d]pyrimidine-diones in Water: A Triply Green Synthesis

Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran 1993893973, Iran
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Author to whom correspondence should be addressed.
Academic Editor: Romano V. A. Orru
Received: 25 February 2016 / Revised: 12 March 2016 / Accepted: 24 March 2016 / Published: 1 April 2016
(This article belongs to the Special Issue MCRs and Related One-Pot Organic Synthesis)
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Abstract

A novel one pot synthesis of pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine-diones, via a five-component reaction, involving, hydrazine hydrate, ethyl acetoacetate, and 1,3-dimethyl barbituric acid, an appropriate aryl aldehydes and ammonium acetate catalyzed via both of heterogeneous and homogeneous catalysis in water, is reported. View Full-Text
Keywords: pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine-diones; green synthesis; multi-component reaction; in water reaction pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine-diones; green synthesis; multi-component reaction; in water reaction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Heravi, M.M.; Daraie, M. A Novel and Efficient Five-Component Synthesis of Pyrazole Based Pyrido[2,3-d]pyrimidine-diones in Water: A Triply Green Synthesis. Molecules 2016, 21, 441.

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