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Molecules 2016, 21(2), 250; doi:10.3390/molecules21020250

Multicomponent Synthesis and Evaluation of New 1,2,3-Triazole Derivatives of Dihydropyrimidinones as Acidic Corrosion Inhibitors for Steel

Departamento de Ciencias Básicas, Universidad Autónoma Metropolitana-Azcapotzalco, Av. San Pablo No. 180, Ciudad de México, C.P. 02200, Mexico
Departamento de Ingeniería Metalúrgica, Facultad de Química, Universidad Nacional Autónoma de México, C.U., Ciudad de México, C.P. 04510, Mexico
Departamento de Química, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Apartado Postal 14-740, 07000 Ciudad de México, Mexico
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 23 December 2015 / Revised: 7 February 2016 / Accepted: 17 February 2016 / Published: 22 February 2016
(This article belongs to the Special Issue MCRs and Related One-Pot Organic Synthesis)
View Full-Text   |   Download PDF [1591 KB, uploaded 22 February 2016]   |  


An efficient one-pot synthesis of 1,2,3-triazole derivatives of dihydropyrimidinones has been developed using two multicomponent reactions. The aldehyde-1,2,3-triazoles were obtained in good yields from in situ-generated organic azides and O-propargylbenzaldehyde. The target heterocycles were synthesized through the Biginelli reaction in which the aldehyde-1,2,3-triazoles reacted with ethyl acetoacetate and urea in the presence of Ce(OTf)3 as the catalyst. The corrosion inhibition of steel grade API 5 L X52 in 1 M HCl by the synthesized compounds was investigated using the electrochemical impedance spectroscopy technique. The measurements revealed that these heterocycles are promising candidates to inhibit acidic corrosion of steel. View Full-Text
Keywords: multicomponent synthesis; dihydropyrimidinone; 1,2,3-triazole; corrosion inhibitor; steel multicomponent synthesis; dihydropyrimidinone; 1,2,3-triazole; corrosion inhibitor; steel

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González-Olvera, R.; Román-Rodríguez, V.; Negrón-Silva, G.E.; Espinoza-Vázquez, A.; Rodríguez-Gómez, F.J.; Santillan, R. Multicomponent Synthesis and Evaluation of New 1,2,3-Triazole Derivatives of Dihydropyrimidinones as Acidic Corrosion Inhibitors for Steel. Molecules 2016, 21, 250.

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