Next Article in Journal
Comparison of Anti-Oxidant and Anti-Inflammatory Effects between Fresh and Aged Black Garlic Extracts
Previous Article in Journal
Synthesis of Novel Quaternary Ammonium Salts and Their in Vitro Antileishmanial Activity and U-937 Cell Cytotoxicity
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessCommunication
Molecules 2016, 21(4), 371; doi:10.3390/molecules21040371

Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121

1
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China
2
College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 2 February 2016 / Revised: 8 March 2016 / Accepted: 14 March 2016 / Published: 29 March 2016
(This article belongs to the Section Metabolites)
View Full-Text   |   Download PDF [759 KB, uploaded 29 March 2016]   |  

Abstract

Activity-guided isolation of the fermentation broth of the deep-sea derived fungus Acaromyces ingoldii FS121, which was obtained from the China South Sea, yielded a new naphtha-[2,3-b]pyrandione analogue, acaromycin A (1) and a new thiazole analogue, acaromyester A (2), as well as the known compound (+)-cryptosporin (3). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) spectra. Compounds 13 were evaluated for in vitro growth inhibitory activities against four tumor cell lines (MCF-7, NCI-H460, SF-268 and HepG-2), wherein compounds 1 and 3 exhibited considerable growth inhibitory effects, with IC50 values less than 10 µM. View Full-Text
Keywords: Acaromyces ingoldii; secondary metabolites; deep-sea derived fungus; cell growth inhibition Acaromyces ingoldii; secondary metabolites; deep-sea derived fungus; cell growth inhibition
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Gao, X.-W.; Liu, H.-X.; Sun, Z.-H.; Chen, Y.-C.; Tan, Y.-Z.; Zhang, W.-M. Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121. Molecules 2016, 21, 371.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top