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Molecules 2016, 21(4), 371; doi:10.3390/molecules21040371

Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121

State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China
College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 2 February 2016 / Revised: 8 March 2016 / Accepted: 14 March 2016 / Published: 29 March 2016
(This article belongs to the Section Metabolites)
View Full-Text   |   Download PDF [759 KB, uploaded 29 March 2016]   |  


Activity-guided isolation of the fermentation broth of the deep-sea derived fungus Acaromyces ingoldii FS121, which was obtained from the China South Sea, yielded a new naphtha-[2,3-b]pyrandione analogue, acaromycin A (1) and a new thiazole analogue, acaromyester A (2), as well as the known compound (+)-cryptosporin (3). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) spectra. Compounds 13 were evaluated for in vitro growth inhibitory activities against four tumor cell lines (MCF-7, NCI-H460, SF-268 and HepG-2), wherein compounds 1 and 3 exhibited considerable growth inhibitory effects, with IC50 values less than 10 µM. View Full-Text
Keywords: Acaromyces ingoldii; secondary metabolites; deep-sea derived fungus; cell growth inhibition Acaromyces ingoldii; secondary metabolites; deep-sea derived fungus; cell growth inhibition

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gao, X.-W.; Liu, H.-X.; Sun, Z.-H.; Chen, Y.-C.; Tan, Y.-Z.; Zhang, W.-M. Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121. Molecules 2016, 21, 371.

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