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Molecules 2016, 21(3), 298; doi:10.3390/molecules21030298

Rhubarb Anthraquinones Protect Rats against Mercuric Chloride (HgCl2)-Induced Acute Renal Failure

1
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100094, China
2
China Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China
3
Integrative Medicine Center, 302 Military Hospital, Beijing 100039, China
4
Beijing Friendship Hospital Attached of Capital Medical University, Beijing 100050, China
5
Experimental Animal Center, 302 Military Hospital, Beijing 100039, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 18 January 2016 / Revised: 15 February 2016 / Accepted: 23 February 2016 / Published: 8 March 2016
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [3273 KB, uploaded 8 March 2016]   |  

Abstract

Mercury (Hg) causes severe nephrotoxicity in subjects with excess exposure. This work attempted to identify whether a natural medicine—rhubarb—has protective effects against mercuric chloride (HgCl2)-induced acute renal failure (ARF), and which of its components contributed most to the treatment. Total rhubarb extract (TR) were separated to the total anthraquinones (TA), the total tannins (TT) and remaining component extract (RC). Each extract was orally pre-administered to rats for five successive days followed by HgCl2 injection to induce kidney injury. Subsequently, renal histopathology and biochemical examinations were performed in vitro to evaluate the protective effects. Pharmacological studies showed that TR and TA, but not TT or RC manifested significant protection activity against HgCl2-induced ARF. There were also significant declines of serum creatine, urea nitrogen values and increases of total protein albumin levels in TR and TA treated groups compared to HgCl2 alone (p < 0.05). At last, the major components in TA extract were further identified as anthraquinones by liquid chromatography coupled mass spectroscopy. This study thus provides observational evidences that rhubarb could ameliorate HgCl2-induced ARF and its anthraquinones in particular are the effective components responsible for this activity in rhubarb extract. View Full-Text
Keywords: mercury; acute renal failure; rhubarb; anthraquinones; protection mercury; acute renal failure; rhubarb; anthraquinones; protection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gao, D.; Zeng, L.-N.; Zhang, P.; Ma, Z.-J.; Li, R.-S.; Zhao, Y.-L.; Zhang, Y.-M.; Guo, Y.-M.; Niu, M.; Bai, Z.-F.; Xiao, X.-H.; Gao, W.-W.; Wang, J.-B. Rhubarb Anthraquinones Protect Rats against Mercuric Chloride (HgCl2)-Induced Acute Renal Failure. Molecules 2016, 21, 298.

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