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Molecules 2016, 21(3), 280; doi:10.3390/molecules21030280

Targeting Reactive Carbonyl Species with Natural Sequestering Agents

1
Department of Nano Science & Mechatronics Engineering, College of Science and Technology, Konkuk University, Chungju-si 27478, Korea
2
Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University, Chungju-si 27478, Korea
3
Interdisciplinary Research Center for Health, Konkuk University, Chungju-si 27478, Korea
4
Department of Pharmaceutical Sciences Pietro Pratesi, Università degli Studi di Milano, via Mangiagalli 25, Milan 20133, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Maurizio Battino and Etsuo Niki
Received: 3 January 2016 / Revised: 23 February 2016 / Accepted: 23 February 2016 / Published: 27 February 2016
(This article belongs to the Special Issue 20th Anniversary of Molecules—Recent Advances in Natural Products)
View Full-Text   |   Download PDF [873 KB, uploaded 27 February 2016]   |  

Abstract

Reactive carbonyl species generated by the oxidation of polyunsaturated fatty acids and sugars are highly reactive due to their electrophilic nature, and are able to easily react with the nucleophilic sites of proteins as well as DNA causing cellular dysfunction. Levels of reactive carbonyl species and their reaction products have been reported to be elevated in various chronic diseases, including metabolic disorders and neurodegenerative diseases. In an effort to identify sequestering agents for reactive carbonyl species, various analytical techniques such as spectrophotometry, high performance liquid chromatography, western blot, and mass spectrometry have been utilized. In particular, recent advances using a novel high resolution mass spectrometry approach allows screening of complex mixtures such as natural products for their sequestering ability of reactive carbonyl species. To overcome the limited bioavailability and bioefficacy of natural products, new techniques using nanoparticles and nanocarriers may offer a new attractive strategy for increased in vivo utilization and targeted delivery of bioactives. View Full-Text
Keywords: reactive carbonyl species; natural products; bioefficacy; nanotechniques reactive carbonyl species; natural products; bioefficacy; nanotechniques
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Hwang, S.W.; Lee, Y.-M.; Aldini, G.; Yeum, K.-J. Targeting Reactive Carbonyl Species with Natural Sequestering Agents. Molecules 2016, 21, 280.

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