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Molecules 2016, 21(3), 232; doi:10.3390/molecules21030232

Cytotoxic 1,3-Thiazole and 1,2,4-Thiadiazole Alkaloids from Penicillium oxalicum: Structural Elucidation and Total Synthesis

1
Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China
2
China Three Gorges University People’s Hospital & Yichang First People’s Hospital, Yichang 443000, China
3
Hubei Key Laboratory of Natural Products Research and Development, Medical College, China Three Gorges University, Yichang 443002, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 25 January 2016 / Revised: 14 February 2016 / Accepted: 15 February 2016 / Published: 26 February 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [2339 KB, uploaded 26 February 2016]   |  

Abstract

Two new thiazole and thiadiazole alkaloids, penicilliumthiamine A and B (2 and 3), were isolated from the culture broth of Penicillium oxalicum, a fungus found in Acrida cinerea. Their structures were elucidated mainly by spectroscopic analysis, total synthesis and X-ray crystallographic analysis. Biological evaluations indicated that compound 1, 3a and 3 exhibit potent cytotoxicity against different cancer cell lines through inhibiting the phosphorylation of AKT/PKB (Ser 473), one of important cancer drugs target. View Full-Text
Keywords: Penicillium oxalicum; alkaloids; total synthesis; structure elucidation; cytotoxicity Penicillium oxalicum; alkaloids; total synthesis; structure elucidation; cytotoxicity
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Yang, Z.; Huang, N.; Xu, B.; Huang, W.; Xie, T.; Cheng, F.; Zou, K. Cytotoxic 1,3-Thiazole and 1,2,4-Thiadiazole Alkaloids from Penicillium oxalicum: Structural Elucidation and Total Synthesis. Molecules 2016, 21, 232.

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