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Molecules 2016, 21(3), 281; doi:10.3390/molecules21030281

Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood

1
The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Traditional Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201210, China
2
Shanghai R & D Centre for Standardization of Chinese Medicines, Shanghai 201203, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 20 January 2016 / Revised: 22 February 2016 / Accepted: 23 February 2016 / Published: 27 February 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1037 KB, uploaded 27 February 2016]   |  

Abstract

Three new sesquiterpenoids (13) and one new sesquiterpenoid derivative (4), along with three known sesquiterpenoids (57), were isolated from the 95% ethanolic extract of Chinese eaglewood [Aquilaria sinensis (Lour.) Gilg]. The structures of these compounds were elucidated through extensive analysis of spectroscopic data including IR, NMR, HRESIMS, and X-ray diffraction experiments. In addition, the above new compounds were detected for their bioactivities against LPS-induced NO production in RAW 264.7 cells. Among them, compound 2 exhibited obvious anti-inflammatory activity with an IC50 value of 8.1 μM. View Full-Text
Keywords: Chinese eaglewood; sesquiterpenoids; sesquiterpenoid derivative; X-ray diffraction; anti-inflammatory activity Chinese eaglewood; sesquiterpenoids; sesquiterpenoid derivative; X-ray diffraction; anti-inflammatory activity
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Zhao, H.; Peng, Q.; Han, Z.; Yang, L.; Wang, Z. Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood. Molecules 2016, 21, 281.

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