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Molecules 2016, 21(2), 238; doi:10.3390/molecules21020238

Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles

Department of Chemistry, National Changhua University of Education, Changhua 50007, Taiwan
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Academic Editor: Derek J. McPhee
Received: 27 January 2016 / Revised: 13 February 2016 / Accepted: 15 February 2016 / Published: 19 February 2016
(This article belongs to the Section Organic Synthesis)
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Abstract

A procedure has been developed for synthesis of 2-alkenyl-2H-indazoles starting from 2-(2-carbonylmethyl)-2H-indazoles, which are prepared by gallium/aluminium- and aluminium-mediated, direct, regioselective alkylation of indazoles with α-bromocarbonyl compounds. The structure of 3-(2H-indazol-2-yl)-2H-chromen-2-one was proven by X-ray crystallography. The styrene- and coumarin-2H-indazoles produced by using the new method were found to have interesting fluorescence properties. View Full-Text
Keywords: indazoles; coumarin; regioselective alkylation; styrene; fluorescence indazoles; coumarin; regioselective alkylation; styrene; fluorescence
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MDPI and ACS Style

Lin, M.-H.; Liang, K.-Y.; Tsai, C.-H.; Chen, Y.-C.; Hsiao, H.-C.; Li, Y.-S.; Chen, C.-H.; Wu, H.-C. Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles. Molecules 2016, 21, 238.

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