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Molecules 2016, 21(2), 237; doi:10.3390/molecules21020237

Antifungal Activity of Isoliquiritin and Its Inhibitory Effect against Peronophythora litchi Chen through a Membrane Damage Mechanism

Key Laboratory of Natural Pesticide and Chemical Biology, College of Agriculture, South China Agricultural University, Guangzhou 510642, China
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Academic Editor: Derek J. McPhee
Received: 17 January 2016 / Revised: 13 February 2016 / Accepted: 14 February 2016 / Published: 19 February 2016
(This article belongs to the Section Natural Products)
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Abstract

This study investigated the antifungal activity and potential antifungal mechanism(s) of isoliquiritin against P. litchi Chen, one of the main litchi pathogens. The antifungal activity of isoliquiritin against P. litchi Chen had been proven in a dose-dependent manner through in vitro (mycelial growth and sporangia germination) and in vivo (detached leaf) tests. Results revealed that isoliquiritin exhibited significant antifungal activity against the tested pathogens, especially, P. litchi Chen, with a minimum inhibitory concentration of 27.33 mg/L. The morphology of P. litchi Chen was apparently changed by isoliquiritin through cytoplasm leakage and distortion of mycelia. The cell membrane permeability of the P. litchi Chen increased with the increasing concentration of isoliquiritin, as evidenced by a rise in relative electric conductivity and a decrease in reducing sugar contents. These results indicated that the antifungal effects of isoliquiritin could be explained by a membrane lesion mechanism causing damage to the cell membrane integrity leading to the death of mycelial cells. Taken together, isoliquiritin may be used as a natural alternative to commercial fungicides or a lead compound to develop new fungicides for the control of litchi downy blight. View Full-Text
Keywords: isoliquiritin; Peronophythora litchi Chen; antifungal; SEM; mechanism isoliquiritin; Peronophythora litchi Chen; antifungal; SEM; mechanism
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Luo, J.; Li, Z.; Wang, J.; Weng, Q.; Chen, S.; Hu, M. Antifungal Activity of Isoliquiritin and Its Inhibitory Effect against Peronophythora litchi Chen through a Membrane Damage Mechanism. Molecules 2016, 21, 237.

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