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Molecules 2016, 21(2), 142; doi:10.3390/molecules21020142

Preventive and Therapeutic Effects of Chinese Herbal Compounds against Hepatocellular Carcinoma

1
Department of Oncology and Institute of Traditional Chinese Medicine in Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
2
Department of Science & Technology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 202032, China
3
Department of Plastic & Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, The Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200011, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 16 November 2015 / Revised: 13 January 2016 / Accepted: 20 January 2016 / Published: 27 January 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [482 KB, uploaded 27 January 2016]   |  

Abstract

Traditional Chinese Medicines, unique biomedical and pharmaceutical resources, have been widely used for hepatocellular carcinoma (HCC) prevention and treatment. Accumulated Chinese herb-derived compounds with significant anti-cancer effects against HCC have been identified. Chinese herbal compounds are effective in preventing carcinogenesis, inhibiting cell proliferation, arresting cell cycle, inducing apoptosis, autophagy, cell senescence and anoikis, inhibiting epithelial-mesenchymal transition, metastasis and angiogenesis, regulating immune function, reversing drug resistance and enhancing the effects of chemotherapy in HCC. This paper comprehensively reviews these compounds and their effects on HCC. Finally, the perspectives and rational application of herbal compounds for HCC management are discussed. View Full-Text
Keywords: hepatocellular carcinoma; Chinese herbal compound; phytopharmacology; prevention; treatment hepatocellular carcinoma; Chinese herbal compound; phytopharmacology; prevention; treatment
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Hu, B.; An, H.-M.; Wang, S.-S.; Chen, J.-J.; Xu, L. Preventive and Therapeutic Effects of Chinese Herbal Compounds against Hepatocellular Carcinoma. Molecules 2016, 21, 142.

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