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Molecules 2016, 21(2), 136; doi:10.3390/molecules21020136

The Inhibitory Mechanisms Study of 5,6,4′-Trihydroxy-7,3′-Dimethoxyflavone against the LPS-Induced Macrophage Inflammatory Responses through the Antioxidant Ability

1
School of Pharmacy, China Medical University, Taichung 404, Taiwan
2
Department of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan
3
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
4
Institute of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan
5
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 2 December 2015 / Revised: 14 January 2016 / Accepted: 18 January 2016 / Published: 22 January 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [3245 KB, uploaded 22 January 2016]   |  

Abstract

The whole plant of Anisomeles ovata has been widely used in Taiwan for treating inflammation-related skin and liver diseases, however, the detailed pharmacology mechanisms have yet to be elucidated. In the present study, one of the major components, 5,6,4′-trihydroxy-7,3′-dimethoxyflavone (5-TDMF), was purified from a methanol extract of Anisomeles ovata. A pharmacological study of this compound suggests that 5-TDMF possesses potent free radical scavenging activity both in vitro and ex vivo. Furthermore, 5-TDMF reduces nitric oxide and pro-inflammatory cytokine production in LPC-treated RAW 264.7 cells through the attenuation of nitric oxide synthase and cyclooxygenase-2. Additional experiments suggest that of 5-TDMF interferes with nuclear factor-κB translocation and mitogen-activated protein kinase pathways. These results identify 5-TDMF as an anti-oxidant and anti-inflammatory compound, explain the pharmacologic function of Anisomeles ovata and suggest its great potential as a new anti-inflammatory remedy. View Full-Text
Keywords: Anisomeles ovata; 5,6,4′-trihydroxy-7,3′-dimethoxyflavone; anti-inflammatory; anti-oxidant; reactive oxygen species Anisomeles ovata; 5,6,4′-trihydroxy-7,3′-dimethoxyflavone; anti-inflammatory; anti-oxidant; reactive oxygen species
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, S.-H.; Liang, C.-H.; Liang, F.-P.; Ding, H.-Y.; Lin, S.-P.; Huang, G.-J.; Lin, W.-C.; Juang, S.-H. The Inhibitory Mechanisms Study of 5,6,4′-Trihydroxy-7,3′-Dimethoxyflavone against the LPS-Induced Macrophage Inflammatory Responses through the Antioxidant Ability. Molecules 2016, 21, 136.

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