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Molecules 2016, 21(11), 1425; doi:10.3390/molecules21111425

Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats

1
Department of Pathology, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico
2
Department of Pharmacology, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico
3
Facultad de Química, Department of Biology, Edificio B, Segundo Piso, Laboratorio 209, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Mexico City 04510, Mexico
4
Department of Physiology, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico
5
Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Vasco de Quiroga 15, Sección XVI, Tlalpan, Mexico City 14000, Mexico
6
Electromechanical Instrumentation, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano 1, Sección XVI, Tlalpan, Mexico City 14080, Mexico
Israel Pérez-Torres and Juan Carlos Torres-Narváez, share the first authorship of this paper.
*
Author to whom correspondence should be addressed.
Academic Editor: Alan J. Slusarenko
Received: 29 September 2016 / Revised: 16 October 2016 / Accepted: 21 October 2016 / Published: 26 October 2016
(This article belongs to the Special Issue The Chemistry of Alliums)
View Full-Text   |   Download PDF [885 KB, uploaded 26 October 2016]   |  

Abstract

The antioxidant properties of aged garlic extract (AGE) on cardiovascular functioning (CF) in metabolic syndrome (MS) remains poorly studied. Here we study the AGE effects on CF in a rat model of MS. Control rats plus saline solution (C + SS), MS rats (30% sucrose in drinking water from weaning) plus saline solution (MS + SS), control rats receiving AGE (C + AGE 125 mg/Kg/12 h) and MS rats with AGE (MS + AGE) were studied. MS + SS had increased triglycerides, systolic blood pressure, insulin, leptin, HOMA index, and advanced glycation end products. AGE returned their levels to control values (p < 0.01). Cholesterol was decreased by AGE (p = 0.05). Glutathion and GPx activity were reduced in MS + SS rats and increased with AGE (p = 0.05). Lipid peroxidation was increased in MS + SS and AGE reduced it (p = 0.001). Vascular functioning was deteriorated by MS (increased vasocontraction and reduced vasodilation) and AGE improved it (p = 0.001). Coronary vascular resistance was increased in MS rats and AGE decreased it (p = 0.001). Cardiac performance was not modified by MS but AGE increased it. NO measured in the perfusate liquid from the heart and serum citrulline, nitrites/nitrates were decreased in MS and AGE increased them (p < 0.01). In conclusion, AGE reduces MS-induced cardiovascular risk, through its anti-oxidant properties. View Full-Text
Keywords: aged garlic extract; metabolic syndrome; cardiovascular functioning; oxidative stress aged garlic extract; metabolic syndrome; cardiovascular functioning; oxidative stress
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Pérez-Torres, I.; Torres-Narváez, J.C.; Pedraza-Chaverri, J.; Rubio-Ruiz, M.E.; Díaz-Díaz, E.; del Valle-Mondragón, L.; Martínez-Memije, R.; Varela López, E.; Guarner-Lans, V. Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats. Molecules 2016, 21, 1425.

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