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Molecules 2016, 21(11), 1415; doi:10.3390/molecules21111415

Antimalarial Activity of the Chemical Constituents of the Leaf Latex of Aloe pulcherrima Gilbert and Sebsebe

1
Department of Pharmacy, College of Health Sciences, Wollo University, P.O. Box 1145, Dessie, Ethiopia
2
Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
*
Author to whom correspondence should be addressed.
Academic Editor: David J. Newman
Received: 29 August 2016 / Revised: 11 October 2016 / Accepted: 17 October 2016 / Published: 28 October 2016
(This article belongs to the Special Issue Natural Product: A Continuing Source of Novel Drug Leads)
View Full-Text   |   Download PDF [389 KB, uploaded 28 October 2016]   |  

Abstract

Malaria is one of the three major global public health threats due to a wide spread resistance of the parasites to the standard antimalarial drugs. Considering this growing problem, the ethnomedicinal approach in the search for new antimalarial drugs from plant sources has proven to be more effective and inexpensive. The leaves of Aloe pulcherrima Gilbert and Sebsebe, an endemic Ethiopian plant, are locally used for the treatment of malaria and other infectious diseases. Application of the leaf latex of A. pulcherrima on preparative silica gel TLC led to the isolation of two C-glycosylated anthrones, identified as nataloin (1) and 7-hydroxyaloin (2) by spectroscopic techniques (UV, IR, 1H- and 13C-NMR, HR-ESIMS). Both the latex and isolated compounds displayed antimalarial activity in a dose-independent manner using a four-day suppressive test, with the highest percent suppression of 56.2% achieved at 200 mg/kg/day for 2. The results indicate that both the leaf latex of A. pulcherrima and its two major constituents are endowed with antiplasmodial activities, which support the traditional use of the leaves of the plant for the treatment of malaria. View Full-Text
Keywords: Aloe pulcherrima; antimalarial; nataloin; 7-hydroxyaloin; four-day suppressive Aloe pulcherrima; antimalarial; nataloin; 7-hydroxyaloin; four-day suppressive
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Teka, T.; Bisrat, D.; Yeshak, M.Y.; Asres, K. Antimalarial Activity of the Chemical Constituents of the Leaf Latex of Aloe pulcherrima Gilbert and Sebsebe. Molecules 2016, 21, 1415.

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