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Molecules 2016, 21(10), 1405; doi:10.3390/molecules21101405

Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library

1
Department of Chemistry “Ugo Schiff”, University of Florence, Via della Lastruccia 13, 50019 Sesto Fiorentino, Florence, Italy
2
Department of Clinical and Experimental Biomedical Science “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 18 August 2016 / Revised: 12 October 2016 / Accepted: 15 October 2016 / Published: 20 October 2016
(This article belongs to the Special Issue Diversity Oriented Synthesis 2016)
View Full-Text   |   Download PDF [7033 KB, uploaded 20 October 2016]   |  

Abstract

The application of a cell-based growth inhibition on a library of skeletally different glycomimetics allowed for the selection of a hexahydro-2H-furo[3,2-b][1,4]oxazine compound as candidate inhibitors of MDA-MB-231 cell growth. Subsequent synthesis of analogue compounds and preliminary biological studies validated the selection of a valuable hit compound with a novel polyhydroxylated structure for the modulation of the breast carcinoma cell cycle mechanism. View Full-Text
Keywords: heterocycles; sugars; chemical diversity; cancer heterocycles; sugars; chemical diversity; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lenci, E.; Innocenti, R.; Biagioni, A.; Menchi, G.; Bianchini, F.; Trabocchi, A. Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library. Molecules 2016, 21, 1405.

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