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Molecules 2016, 21(10), 1385; doi:10.3390/molecules21101385

New Sesquiterpenoids and Anti-Platelet Aggregation Constituents from the Rhizomes of Curcuma zedoaria

1
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
2
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
3
Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
4
Department of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813, Taiwan
5
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
6
Department of Biotechnology, Asia University, Taichung 413, Taiwan
7
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
8
Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 16 September 2016 / Revised: 8 October 2016 / Accepted: 12 October 2016 / Published: 17 October 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1062 KB, uploaded 17 October 2016]   |  

Abstract

Two new sesquiterpenoids—13-hydroxycurzerenone (1) and 1-oxocurzerenone (2)—have been isolated from the rhizomes of Curcuma zedoaria, together with 13 known compounds (315). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compounds, 13-hydroxycurzerenone (1), 1-oxocurzerenone (2), curzerenone (3), germacrone (4), curcolone (5), procurcumenol (6), ermanin (7), curcumin (8), and a mixture of stigmast-4-en-3,6-dione (12) and stigmasta-4,22-dien-3,6-dione (13) exhibited inhibition (with inhibition % in the range of 21.28%–67.58%) against collagen-induced platelet aggregation at 100 μM. Compounds 1, 5, 7, 8, and the mixture of 12 and 13 inhibited arachidonic acid (AA)-induced platelet aggregation at 100 μM with inhibition % in the range of 23.44%–95.36%. View Full-Text
Keywords: Curcuma zedoaria; Zingiberaceae; rhizomes; sesquiterpenoids; anti-platelet aggregation Curcuma zedoaria; Zingiberaceae; rhizomes; sesquiterpenoids; anti-platelet aggregation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chen, J.-J.; Tsai, T.-H.; Liao, H.-R.; Chen, L.-C.; Kuo, Y.-H.; Sung, P.-J.; Chen, C.-L.; Wei, C.-S. New Sesquiterpenoids and Anti-Platelet Aggregation Constituents from the Rhizomes of Curcuma zedoaria. Molecules 2016, 21, 1385.

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