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Molecules 2016, 21(10), 1344; doi:10.3390/molecules21101344

Picrotoxane Sesquiterpene Glycosides and a Coumarin Derivative from Coriaria nepalensis and Their Neurotrophic Activity

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China
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Academic Editor: Isabel C. F. R. Ferreira
Received: 10 September 2016 / Revised: 7 October 2016 / Accepted: 9 October 2016 / Published: 12 October 2016
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Two picrotoxane sesquiterpene lactone glycosides, nepalactones A (1) and B (2), and one new coumarin, nepalarin (3), were isolated from the root barks of the poisonous plant Coriaria nepalensis. Their structures were elucidated via HRESIMS and 1D and 2D NMR spectroscopic analyses, and further verified via transformation methods. In addition, compounds 13 and five semisynthetic congeners (1ae) were assayed for the activity to induce neurite outgrowth in rat pheochromocytoma (PC12) cells. As a result, nepalactone A derivative 1c and nepalarin (3) significantly enhanced nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells. View Full-Text
Keywords: Coriaria nepalensis; Coriariaceae; natural products; picrotoxane; sesquiterpene; neurite outgrowth-potentiating activity; neurotrophic activity Coriaria nepalensis; Coriariaceae; natural products; picrotoxane; sesquiterpene; neurite outgrowth-potentiating activity; neurotrophic activity
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Wang, Y.-Y.; Tian, J.-M.; Zhang, C.-C.; Luo, B.; Gao, J.-M. Picrotoxane Sesquiterpene Glycosides and a Coumarin Derivative from Coriaria nepalensis and Their Neurotrophic Activity. Molecules 2016, 21, 1344.

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