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Molecules 2016, 21(10), 1313; doi:10.3390/molecules21101313

2-(2-Phenylethyl)chromone Derivatives of Agarwood Originating from Gyrinops salicifolia

1
Horticultural and Garden College, Hainan University, Haikou 570228, Hainan, China
2
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, Hainan, China
*
Authors to whom correspondence should be addressed.
Received: 1 September 2016 / Accepted: 26 September 2016 / Published: 3 October 2016
(This article belongs to the Section Natural Products)
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Abstract

Three new2-(2-phenylethyl)chromone derivatives (1–3) and a new2-(2-phenylethenyl)chromone derivative (4), together with two known 2-(2-phenylethyl)chromone derivatives (5–6), were isolated from agarwood originating from Gyrinops salicifolia Ridl. The structures of compounds 1–4 were elucidated by comprehensive spectroscopic techniques (UV, IR, 1D and 2D-NMR) and MS analysis, as well as by comparison with the literature. Compounds 1, 2, and 5 showed moderate cytotoxicity against human tumor K562, BEL-7402, and SGC-7901 cell lines with IC50 values of 5.76 to 20.1 µM. View Full-Text
Keywords: 2-(2-phenylethyl)chromone derivative; 2-(2-phenylethenyl)chromone derivative; agarwood; Gyrinops salicifolia; cytotoxicity 2-(2-phenylethyl)chromone derivative; 2-(2-phenylethenyl)chromone derivative; agarwood; Gyrinops salicifolia; cytotoxicity
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Shao, H.; Mei, W.-L.; Dong, W.-H.; Gai, C.-J.; Li, W.; Zhu, G.-P.; Dai, H.-F. 2-(2-Phenylethyl)chromone Derivatives of Agarwood Originating from Gyrinops salicifolia. Molecules 2016, 21, 1313.

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