Increasing the Level of IRS-1 and Insulin Pathway Sensitivity by Natural Product Carainterol A
AbstractCarainterol A is a eudesmane sesquiterpenoid extracted from Caragana intermedia. We have reported that carainterol A showed potent glucose consumption activity in C2C12 muscle cells and the db/db mouse model. However, the mechanism of the hypoglycemic effect of carainterol A remains elusive. In this article, we present a network pharmacology approach to predict the target and signaling pathway of carainterol A which was subsequently validated in HepG2 cells. It was demonstrated that carainterol A could increase the protein levels of IRS-1 and the downstream protein kinase AKT phosphorylation at a low micromolar level. These findings suggest that carainterol A can be a valuable lead compound and a promising chemical probe for the insulin signaling pathway. View Full-Text
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Ma, K.; Miao, Y.; Gao, Y.; Tian, J.; Gao, L.; Ye, D.; Qin, X. Increasing the Level of IRS-1 and Insulin Pathway Sensitivity by Natural Product Carainterol A. Molecules 2016, 21, 1303.
Ma K, Miao Y, Gao Y, Tian J, Gao L, Ye D, Qin X. Increasing the Level of IRS-1 and Insulin Pathway Sensitivity by Natural Product Carainterol A. Molecules. 2016; 21(10):1303.Chicago/Turabian Style
Ma, Kaiqing; Miao, Yanhong; Gao, Yao; Tian, Junsheng; Gao, Li; Ye, Deyong; Qin, Xuemei. 2016. "Increasing the Level of IRS-1 and Insulin Pathway Sensitivity by Natural Product Carainterol A." Molecules 21, no. 10: 1303.
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