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Molecules 2016, 21(10), 1303; doi:10.3390/molecules21101303

Increasing the Level of IRS-1 and Insulin Pathway Sensitivity by Natural Product Carainterol A

1
Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
2
College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
3
Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 1 September 2016 / Revised: 21 September 2016 / Accepted: 23 September 2016 / Published: 29 September 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1512 KB, uploaded 29 September 2016]   |  

Abstract

Carainterol A is a eudesmane sesquiterpenoid extracted from Caragana intermedia. We have reported that carainterol A showed potent glucose consumption activity in C2C12 muscle cells and the db/db mouse model. However, the mechanism of the hypoglycemic effect of carainterol A remains elusive. In this article, we present a network pharmacology approach to predict the target and signaling pathway of carainterol A which was subsequently validated in HepG2 cells. It was demonstrated that carainterol A could increase the protein levels of IRS-1 and the downstream protein kinase AKT phosphorylation at a low micromolar level. These findings suggest that carainterol A can be a valuable lead compound and a promising chemical probe for the insulin signaling pathway. View Full-Text
Keywords: carainterol A; network pharmacology; insulin receptor substrate 1; insulin signaling pathway carainterol A; network pharmacology; insulin receptor substrate 1; insulin signaling pathway
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MDPI and ACS Style

Ma, K.; Miao, Y.; Gao, Y.; Tian, J.; Gao, L.; Ye, D.; Qin, X. Increasing the Level of IRS-1 and Insulin Pathway Sensitivity by Natural Product Carainterol A. Molecules 2016, 21, 1303.

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