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Molecules 2016, 21(10), 1283; doi:10.3390/molecules21101283

Terminamines K–S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis

Tianjin Key Laboratory on Technologies Enabling Development Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
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Academic Editor: Derek J. McPhee
Received: 11 August 2016 / Revised: 12 September 2016 / Accepted: 13 September 2016 / Published: 26 September 2016
(This article belongs to the Section Natural Products)
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Abstract

Nine new pregnane alkaloids (19), together with eight known alkaloids (1017), were isolated from the whole herb of Pachysandra terminalis. Their structures were elucidated on the basis of spectroscopic analyses. In addition, the isolates were examined for their ability to inhibit the migration of MDA-MB-231 cells induced by the chemokine epidermal growth factor (EGF). Alkaloids 1, 5, 7, 9, 12, and 17 presented significant anti-metastasis activities compared with the positive reagent, LY294002. View Full-Text
Keywords: Pachysandra terminalis; Buxaceae; pregnane alkaloids; anti-metastatic activity; structure-activity relationships Pachysandra terminalis; Buxaceae; pregnane alkaloids; anti-metastatic activity; structure-activity relationships
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MDPI and ACS Style

Li, X.-Y.; Yu, Y.; Jia, M.; Jin, M.-N.; Qin, N.; Zhao, C.; Duan, H.-Q. Terminamines K–S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis. Molecules 2016, 21, 1283.

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