Efficient Synthesis and Antibacterial Evaluation of (±)-Yanglingmycin and Its Analogues
AbstractAn efficient synthetic route was developed for the large-scale preparation of (±)-Yanglingmycin and its analogues. Three series of derivatives of (±)-Yanglingmycin were synthesized and the structures of all compounds were elucidated by analyses of NMR and ESI-MS spectra data. Moreover, their antibacterial activities against seven species of bacteria were systematically evaluated by the micro-broth dilution method, most of which displayed considerable activity. It was worth noting that compounds 5b, 5c, 5d, 6g, and 7 were found to be the most promising leading candidates, with peak MIC values of 0.98 μg·mL−1 for Bacillus subtilis, which is superior to positive controls (MIC = 3.91 μg·mL−1). The above results might lay the firm foundation for the design and synthesis of novel antibacterial drugs based on (±)-Yanglingmycin. View Full-Text
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Dan, W.; Geng, H.; Qiao, J.; Guo, R.; Wei, S.; Li, L.; Wu, W.; Zhang, J. Efficient Synthesis and Antibacterial Evaluation of (±)-Yanglingmycin and Its Analogues. Molecules 2016, 21, 96.
Dan W, Geng H, Qiao J, Guo R, Wei S, Li L, Wu W, Zhang J. Efficient Synthesis and Antibacterial Evaluation of (±)-Yanglingmycin and Its Analogues. Molecules. 2016; 21(1):96.Chicago/Turabian Style
Dan, Wenjia; Geng, Huiling; Qiao, Jianwen; Guo, Rui; Wei, Shaopeng; Li, Longbo; Wu, Wenjun; Zhang, Jiwen. 2016. "Efficient Synthesis and Antibacterial Evaluation of (±)-Yanglingmycin and Its Analogues." Molecules 21, no. 1: 96.
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