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Molecules 2016, 21(1), 86; doi:10.3390/molecules21010086

Bioactive Diterpenoids from Clerodendrum kiangsiense

Zhejiang Provincial Key Laboratory for Genetic Improvement and Quality Control of Medicinal Plants, Hangzhou Normal University, Hangzhou 310036, China
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Academic Editor: Derek J. McPhee
Received: 24 December 2015 / Revised: 7 January 2016 / Accepted: 8 January 2016 / Published: 15 January 2016
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Abstract

A new abeo-abietane diterpenoid, 12-methoxy-6,11,14,16-tetrahydroxy-17(15→16)-abeo-5,8,11,13-abietatetraen-3,7-dione (8), was isolated from the hydroalcoholic extract of the herb of Clerodendrum kiangsiense along with seven known diterpenoids (17). Their structures were identified on the basis of spectroscopic analyses including two-dimensional NMR and comparison with literature data. All of these compounds were evaluated for their cytotoxic activities against the growth of human cancer cells lines HL-60, SMMC-7721, A-549 and MCF-7 by the MTT assay. The results showed that cryptojaponol (4), fortunin E (6) and 8 exhibited significant cytotoxicity against four human cancer cell lines. View Full-Text
Keywords: Clerodendrum kiangsiense; abeo-abietane diterpenoid; cytotoxicity Clerodendrum kiangsiense; abeo-abietane diterpenoid; cytotoxicity
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Xu, M.; Wang, S.; Jia, O.; Zhu, Q.; Shi, L. Bioactive Diterpenoids from Clerodendrum kiangsiense. Molecules 2016, 21, 86.

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