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Molecules 2016, 21(1), 82; doi:10.3390/molecules21010082

A New Bioactive Metabolite Isolated from the Red Sea Marine Sponge Hyrtios erectus

1
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt
2
Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
3
Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr el-Aini Street, Cairo 11562, Egypt
4
Department of Clinical Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
*
Author to whom correspondence should be addressed.
Academic Editors: Nancy D. Turner and Isabel C. F. R. Ferreira
Received: 12 December 2015 / Revised: 5 January 2016 / Accepted: 8 January 2016 / Published: 15 January 2016
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [2855 KB, uploaded 15 January 2016]   |  

Abstract

Chemical investigation of the lipophilic fraction of Hyrtios erectus, a Red Sea sponge, yielded a new pentacyclic nitrogen-containing scalarane; 24-methoxypetrosaspongia C (1), together with the previously reported scalaranes sesterstatin 3 (2), 12-deacetyl-12-epi-scalaradial (3) and 12-deacetyl-12,18-di-epi-scalaradial (4). The compounds were identified using HRESIMS, 1D and 2D NMR experiments. The isolated compounds showed growth inhibitory activity against hepatocellular carcinoma (HepG2), colorectal carcinoma (HCT-116) and breast adenocarcinoma cells (MCF-7). View Full-Text
Keywords: Red Sea sponge; Hyrtios erectus; 24-methoxypetrosaspongia C; scalarane sesterterpenes; cancer cell lines; growth inhibitory activity Red Sea sponge; Hyrtios erectus; 24-methoxypetrosaspongia C; scalarane sesterterpenes; cancer cell lines; growth inhibitory activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Elhady, S.S.; El-Halawany, A.M.; Alahdal, A.M.; Hassanean, H.A.; Ahmed, S.A. A New Bioactive Metabolite Isolated from the Red Sea Marine Sponge Hyrtios erectus. Molecules 2016, 21, 82.

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