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Molecules 2016, 21(1), 41; doi:10.3390/molecules21010041

Synthesis of Novel Pyrido[4,3-e][1,2,4]triazino[3,2-c][1,2,4]thiadiazine 6,6-dioxide Derivatives with Potential Anticancer Activity

1
Department of Organic Chemistry, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland
2
Department of Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Ul. Kładki 24, 80-822 Gdańsk, Poland
3
Department of Human Physiology, Medical University of Gdańsk, Ul. Tuwima 15, 80-210 Gdańsk, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 16 November 2015 / Revised: 21 December 2015 / Accepted: 22 December 2015 / Published: 29 December 2015
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Abstract

A series of novel 3-/2,3-substituted pyrido[4,3-e][1,2,4]triazino[3,2-c][1,2,4]thiadiazine 6,6-dioxides 428 have been synthesized by the reaction of 3-amino-2-(4-thioxo-1,4-dihydropyridin-3-yl-sulfonyl)guanidine with either 2-oxoalkanoic acids and its esters, or phenylglyoxylic hydrates in glacial acetic acid. Some of them exhibited reasonable or moderate anticancer activity toward human cancer cell lines, HCT-116, MCF-7 and HeLa. The structure of this novel heterocyclic ring system was confirmed by 1D-NMR and 2D-NMR spectroscopic data including COSY, ROESY and HMBC, elemental analyses and MS spectrometry. View Full-Text
Keywords: pyrido[4,3-e][1,2,4]triazino[3,2-c][1,2,4]thiadiazine; 6,6-dioxides; synthesis; NMR studies; cytotoxic activity pyrido[4,3-e][1,2,4]triazino[3,2-c][1,2,4]thiadiazine; 6,6-dioxides; synthesis; NMR studies; cytotoxic activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sławiński, J.; Grzonek, A.; Żołnowska, B.; Kawiak, A. Synthesis of Novel Pyrido[4,3-e][1,2,4]triazino[3,2-c][1,2,4]thiadiazine 6,6-dioxide Derivatives with Potential Anticancer Activity. Molecules 2016, 21, 41.

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