The Prodrug Approach: A Successful Tool for Improving Drug Solubility
AbstractProdrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug development. This review aims to describe recent advances in the improvement of solubility via the prodrug approach. The main chemical carriers and examples of successful strategies will be discussed, highlighting the advances of this field in the last ten years. View Full-Text
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Jornada, D.H.; dos Santos Fernandes, G.F.; Chiba, D.E.; de Melo, T.R.F.; dos Santos, J.L.; Chung, M.C. The Prodrug Approach: A Successful Tool for Improving Drug Solubility. Molecules 2016, 21, 42.
Jornada DH, dos Santos Fernandes GF, Chiba DE, de Melo TRF, dos Santos JL, Chung MC. The Prodrug Approach: A Successful Tool for Improving Drug Solubility. Molecules. 2016; 21(1):42.Chicago/Turabian Style
Jornada, Daniela H.; dos Santos Fernandes, Guilherme F.; Chiba, Diego E.; de Melo, Thais R.F.; dos Santos, Jean L.; Chung, Man C. 2016. "The Prodrug Approach: A Successful Tool for Improving Drug Solubility." Molecules 21, no. 1: 42.
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