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Molecules 2016, 21(1), 38; doi:10.3390/molecules21010038

Is Stevia rebaudiana Bertoni a Non Cariogenic Sweetener? A Review

Department of Neuroscience, Reproductive and Oral Sciences, Section of Paediatric Dentistry, University of Naples, Federico II, Naples 80131, Italy
Bambino Gesù Hospital, Division of Dentistry and Orthodontics, Rome 00165, Italy
Department of Chemical Sciences, Complesso Universitario di Monte Sant’Angelo, Cupa Nuova Cintia, 21-80126-Napoli, University of Naples, Federico II, Naples 80126, Italy
Inter-University Consortium “SannioTech”, Apollosa (BN) 82030, Italy
Department of Biology, Complesso Universitario di Monte Sant’Angelo, Cupa Nuova Cintia, 21-80126-Napoli, University of Naples, Federico II, Naples 80126, Italy
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editors: Jean Jacques Vanden Eynde and Sylvain Rault
Received: 6 November 2015 / Revised: 14 December 2015 / Accepted: 21 December 2015 / Published: 26 December 2015
View Full-Text   |   Download PDF [750 KB, uploaded 28 December 2015]   |  


Stevia rebaudiana Bertoni is a small perennial shrub of the Asteraceae (Compositae) family that is native to South America, particularly Brazil and Paraguay, where it is known as “stevia” or “honey leaf” for its powerful sweetness. Several studies have suggested that in addition to their sweetness, steviosides and their related compounds, including rebaudioside A and isosteviol, may offer additional therapeutic benefits. These benefits include anti-hyperglycaemic, anti-hypertensive, anti-inflammatory, anti-tumor, anti-diarrheal, diuretic, and immunomodulatory actions. Additionally, critical analysis of the literature supports the anti-bacterial role of steviosides on oral bacteria flora. The aim of this review is to show the emerging results regarding the anti-cariogenic properties of S. rebaudiana Bertoni. Data shown in the present paper provide evidence that stevioside extracts from S. rebaudiana are not cariogenic. Future research should be focused on in vivo studies to evaluate the effects on dental caries of regular consumption of S. rebaudiana extract-based products. View Full-Text
Keywords: Stevia rebaudiana Bertoni; dental caries; sweetener Stevia rebaudiana Bertoni; dental caries; sweetener

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Ferrazzano, G.F.; Cantile, T.; Alcidi, B.; Coda, M.; Ingenito, A.; Zarrelli, A.; Di Fabio, G.; Pollio, A. Is Stevia rebaudiana Bertoni a Non Cariogenic Sweetener? A Review. Molecules 2016, 21, 38.

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