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Molecules 2016, 21(1), 127; doi:10.3390/molecules21010127

The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol

1
Institute of Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, 842 15 Bratislava, Slovakia
2
Department of Genetics, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, 842 15 Bratislava, Slovakia
3
Department of Chromosome Biology, MFPL, University of Vienna, Dr. Bohr-Gasse 9, 1030 Vienna, Austria
4
Department of Chemistry, Faculty of Natural Sciences, Matej Bell University, Tajovského 40, 974 01 Banská Bystrica, Slovakia
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 14 December 2015 / Revised: 11 January 2016 / Accepted: 14 January 2016 / Published: 21 January 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [874 KB, uploaded 21 January 2016]   |  

Abstract

Resveratrol (3,5,4′-trihydroxystilbene) is a phytoalexin produced by plants. Resveratrol is known for its anti-cancer, antiviral and antioxidant properties. We prepared imine analogs of resveratrol ((hydroxyphenyliminomethyl)phenols) and tested their antioxidant activity. All prepared resveratrol analogs were able to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical (GOR) and 2,2′-azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) radicals. The antioxidant activity efficiency correlated with the number and position of hydroxyl groups. The most effective antioxidants were resveratrol analogs containing three hydroxyl groups in the benzylidene part of their molecules. These results provide new insights into the relationship between the chemical structure and biological activity of resveratrol analogs. View Full-Text
Keywords: resveratrol analogs; iminophenols; antioxidant activity resveratrol analogs; iminophenols; antioxidant activity
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Kotora, P.; Šeršeň, F.; Filo, J.; Loos, D.; Gregáň, J.; Gregáň, F. The Scavenging of DPPH, Galvinoxyl and ABTS Radicals by Imine Analogs of Resveratrol. Molecules 2016, 21, 127.

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