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Molecules 2016, 21(1), 115; doi:10.3390/molecules21010115

Biocompatible 3D Matrix with Antimicrobial Properties

1
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1–7 Polizu Street, 011061 Bucharest, Romania
2
Department of Orthopedics and Traumatology, Bucharest University Hospital, 169 Splaiul Independentei, 050098 Bucharest, Romania
3
Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1–7 Polizu Street, 011061 Bucharest, Romania
4
Department of Fetal and Adult Stem Cell Therapy, Institute of Cellular Biology and Pathology of Romanian Academy, 8, B.P. Hasdeu, 050568 Bucharest, Romania
5
Department of Collagen, Branch of Leather and Footwear Research, National Institute of Research and Development for Textile and Leather, 93 I. Minulescu Street, 031215 Bucharest, Romania
6
Microbiology Immunology Department, Faculty of Biology, University of Bucharest, 1–3 Portocalelor Lane, Sector 5, 77206 Bucharest, Romania
7
Research Institute of the University of Bucharest, Life, Environmental and Earth Sciences, Spl. Independentei 91–95, 0500088 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 11 December 2015 / Revised: 12 January 2016 / Accepted: 14 January 2016 / Published: 20 January 2016
(This article belongs to the Special Issue Pharmaceutical Nanotechnology: Novel Approaches)
View Full-Text   |   Download PDF [6193 KB, uploaded 20 January 2016]   |  

Abstract

The aim of this study was to develop, characterize and assess the biological activity of a new regenerative 3D matrix with antimicrobial properties, based on collagen (COLL), hydroxyapatite (HAp), β-cyclodextrin (β-CD) and usnic acid (UA). The prepared 3D matrix was characterized by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Microscopy (FT-IRM), Transmission Electron Microscopy (TEM), and X-ray Diffraction (XRD). In vitro qualitative and quantitative analyses performed on cultured diploid cells demonstrated that the 3D matrix is biocompatible, allowing the normal development and growth of MG-63 osteoblast-like cells and exhibited an antimicrobial effect, especially on the Staphylococcus aureus strain, explained by the particular higher inhibitory activity of usnic acid (UA) against Gram positive bacterial strains. Our data strongly recommend the obtained 3D matrix to be used as a successful alternative for the fabrication of three dimensional (3D) anti-infective regeneration matrix for bone tissue engineering. View Full-Text
Keywords: collagen; hydroxyapatite; usnic acid; Gram positive; biocompatible; S. aureus; drug delivery; cyclodextrins; in vitro collagen; hydroxyapatite; usnic acid; Gram positive; biocompatible; S. aureus; drug delivery; cyclodextrins; in vitro
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Ion, A.; Andronescu, E.; Rădulescu, D.; Rădulescu, M.; Iordache, F.; Vasile, B.Ș.; Surdu, A.V.; Albu, M.G.; Maniu, H.; Chifiriuc, M.C.; Grumezescu, A.M.; Holban, A.M. Biocompatible 3D Matrix with Antimicrobial Properties. Molecules 2016, 21, 115.

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