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Molecules 2015, 20(9), 17208-17220; doi:10.3390/molecules200917208

Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution

1
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, China
2
College of Environment and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063, China
3
Department of Chemistry, William Paterson University of New Jersey, 300 Pompton Road, Wayne, NJ 07470, USA
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 26 May 2015 / Revised: 31 August 2015 / Accepted: 1 September 2015 / Published: 18 September 2015
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [800 KB, uploaded 24 September 2015]   |  

Abstract

An efficient multi-component reaction to synthesize multi-substituted 1,3-oxazolidine compounds of high optical purity was described. All the products were well-characterized and the absolute configuration of one chiral center was determined. The plausible mechanism was proposed and a kinetic resolution of epoxides process was confirmed. View Full-Text
Keywords: 1,3-oxazolidine; asymmetric synthesis; multi-component reaction; kinetic resolution; synthetic methods 1,3-oxazolidine; asymmetric synthesis; multi-component reaction; kinetic resolution; synthetic methods
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hong, X.-W.; Zhou, Y.-Q.; Bai, C.-B.; Wang, N.-X.; Xing, Y.; Zhang, W.; Wang, Y.-J.; Lan, X.-W.; Xie, Y.; Li, Y.-H. Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution. Molecules 2015, 20, 17208-17220.

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