Benzofuranyl Esters: Synthesis, Crystal Structure Determination, Antimicrobial and Antioxidant Activities
AbstractA series of five new 2‐(1‐benzofuran‐2‐yl)‐2‐oxoethyl 4-(un/substituted)benzoates 4(a–e), with the general formula of C8H5O(C=O)CH2O(C=O)C6H4X, X = H, Cl, CH3, OCH3 or NO2, was synthesized in high purity and good yield under mild conditions. The synthesized products 4(a–e) were characterized by FTIR, 1H-, 13C- and 1H-13C HMQC NMR spectroscopic analysis and their 3D structures were confirmed by single-crystal X-ray diffraction studies. These compounds were screened for their antimicrobial and antioxidant activities. The tested compounds showed antimicrobial ability in the order of 4b < 4a < 4c < 4d < 4e and the highest potency with minimum inhibition concentration (MIC) value of 125 µg/mL was observed for 4e. The results of antioxidant activities revealed the highest activity for compound 4e (32.62% ± 1.34%) in diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, 4d (31.01% ± 4.35%) in ferric reducing antioxidant power (FRAP) assay and 4a (27.11% ± 1.06%) in metal chelating (MC) activity. View Full-Text
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Kumar, C.S.C.; Then, L.Y.; Chia, T.S.; Chandraju, S.; Win, Y.-F.; Sulaiman, S.F.; Hashim, N.S.; Ooi, K.L.; Quah, C.K.; Fun, H.-K. Benzofuranyl Esters: Synthesis, Crystal Structure Determination, Antimicrobial and Antioxidant Activities. Molecules 2015, 20, 16566-16581.
Kumar CSC, Then LY, Chia TS, Chandraju S, Win Y-F, Sulaiman SF, Hashim NS, Ooi KL, Quah CK, Fun H-K. Benzofuranyl Esters: Synthesis, Crystal Structure Determination, Antimicrobial and Antioxidant Activities. Molecules. 2015; 20(9):16566-16581.Chicago/Turabian Style
Kumar, C. S.C.; Then, Li Y.; Chia, Tze S.; Chandraju, Siddegowda; Win, Yip-Foo; Sulaiman, Shaida F.; Hashim, Nurul S.; Ooi, Kheng L.; Quah, Ching K.; Fun, Hoong-Kun. 2015. "Benzofuranyl Esters: Synthesis, Crystal Structure Determination, Antimicrobial and Antioxidant Activities." Molecules 20, no. 9: 16566-16581.