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Molecules 2015, 20(9), 16048-16067; doi:10.3390/molecules200916048

Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents

1
Department of Chemistry, Faculty of Sciences, Taibah University, P. O. Box 344, Al-Madinah Al-Munawarah 30002, Saudi Arabia
2
Laboratoire de Chimie & Electrochimie des Complexes Métalliques (LCECM) USTO-MB, Department of Chemistry, Faculty of Sciences, University of Sciences and Technology Mohamed Boudiaf, P. O. Box 1505, El M'nouar, Oran 31000, Algeria
3
Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 9 August 2015 / Revised: 19 August 2015 / Accepted: 25 August 2015 / Published: 2 September 2015
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [756 KB, uploaded 2 September 2015]   |  

Abstract

In the present study, a new series of 2,5-disubstituted-1,3,4-thiadiazole tethered 1,2,4-triazole, 1,3,4-thiadiazole, 1,3,4-oxadiazole and Schiff base derivatives were synthesized and characterized by IR, 1H-NMR, 13C-NMR, MS and elemental analyses. All compounds were screened for their antibacterial, antifungal and antiproliferative activity. Some of the synthesized derivatives have displayed promising biological activity. View Full-Text
Keywords: 1,3,4-thiadiazole; 1,2,4-triazole; 1,3,4-oxadiazole; Schiff base; antimicrobial activity; antitumor activity 1,3,4-thiadiazole; 1,2,4-triazole; 1,3,4-oxadiazole; Schiff base; antimicrobial activity; antitumor activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rezki, N.; Al-Yahyawi, A.M.; Bardaweel, S.K.; Al-Blewi, F.F.; Aouad, M.R. Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents. Molecules 2015, 20, 16048-16067.

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