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Molecules 2015, 20(8), 15060-15071; doi:10.3390/molecules200815060

Antioxidant, Antimicrobial Effects and Phenolic Profile of Lycium barbarum L. Flowers

Department of Pharmaceutical Botany, Iuliu Hațieganu University of Medicine and Pharmacy, 23 Ghe. Marinescu Street, Cluj-Napoca 400010, Romania
Department of Pharmaceutical Technology and Biopharmaceutics, Iuliu Hațieganu University of Medicine and Pharmacy, 12 I. Creangă Street, Cluj-Napoca 400010, Romania
Department of Food Science, University of Agricultural Sciences and Veterinary Medicine, 3-5 Manăştur Street, Cluj-Napoca 400372, Romania
Department of Analytical Chemistry and Instrumental Analysis, Iuliu Hațieganu University of Medicine and Pharmacy, 4 L. Pasteur Street, Cluj-Napoca 400010, Romania
Author to whom correspondence should be addressed.
Academic Editor: Milen I. Georgiev
Received: 28 June 2015 / Revised: 28 June 2015 / Accepted: 10 August 2015 / Published: 17 August 2015
View Full-Text   |   Download PDF [1176 KB, uploaded 17 August 2015]   |  


L. barbarum L. is a widely-accepted nutraceutical presenting highly advantageous nutritive and antioxidant properties. Its flowers have been previously described as a source of diosgenin, β-sitosterol and lanosterol that can be further pharmaceutically developed, but no other data regarding their composition is available. The purpose of this work was to investigate the chemical constituents, antioxidant and antimicrobial activities of L. barbarum flowers, as an alternative resource of naturally-occurring antioxidant compounds. The free radical scavenging activity of the ethanolic extract was tested by TEAC, two enzymatic assays with more physiological relevance and EPR spectroscopy. The presence of several phenolic compounds, such as chlorogenic, p-coumaric and ferulic acids, but also isoquercitrin, rutin and quercitrin, was assessed by an HPLC/MS method. The antioxidant assays revealed that the extract exhibited a moderate antioxidant potential. The antimicrobial activity was mild against Gram-positive bacteria and lacking against Escherichia coli. These findings complete the scarce existing data and offer new perspectives for further pharmaceutical valorization of L. barbarum flowers. View Full-Text
Keywords: antioxidants; antimicrobial; polyphenols; Lycium barbarum L.; flowers; EPR spectroscopy antioxidants; antimicrobial; polyphenols; Lycium barbarum L.; flowers; EPR spectroscopy

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mocan, A.; Vlase, L.; Vodnar, D.C.; Gheldiu, A.-M.; Oprean, R.; Crișan, G. Antioxidant, Antimicrobial Effects and Phenolic Profile of Lycium barbarum L. Flowers. Molecules 2015, 20, 15060-15071.

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