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Molecules 2015, 20(8), 15003-15022; doi:10.3390/molecules200815003

Ethnomedicinal, Phytochemical and Pharmacological Profile of Anthriscus sylvestris as an Alternative Source for Anticancer Lignans

1
Carol Davila University of Medicine and Pharmacy, Traian Vuia 6, Bucharest 020956, Romania
2
Faculty of Biotechnology, University of Agricultural Sciences and Veterinary Medicine, Bucharest 020956, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 9 July 2015 / Revised: 6 August 2015 / Accepted: 11 August 2015 / Published: 17 August 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [755 KB, uploaded 17 August 2015]   |  

Abstract

Anthriscus sylvestris (L.) Hoffm. is a wild herbaceous plant common in most temperate regions. It has been used traditionally to treat headaches, as a tonic, as antitussive, antipyretic, analgesic and diuretic. The plant contains deoxypodophyllotoxin, which is proven to have antitumor and anti-proliferative effects, anti-platelet aggregation, antiviral, anti-inflammatory and insecticidal activity. Deoxypodophyllotoxin is considered to be the plant’s most important constituent, because of its pharmacological properties and because it can be converted into epipodophyllotoxin, the main raw material for the semisynthesis of the cytostatic agents etoposide and teniposide. This work summarizes for the first time the results related to the botanical description, distribution and habitat, phytochemical and pharmacological properties and emphasizes the aspects for future biotechnological research to establish its utility in the therapeutic arsenal. View Full-Text
Keywords: wild chervil; deoxypodophyllotoxin; etoposide; teniposide; topoisomerase inhibitor; flavonoids; antimicrobial; anti-inflammatory; antioxidant wild chervil; deoxypodophyllotoxin; etoposide; teniposide; topoisomerase inhibitor; flavonoids; antimicrobial; anti-inflammatory; antioxidant
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Olaru, O.T.; Niţulescu, G.M.; Orțan, A.; Dinu-Pîrvu, C.E. Ethnomedicinal, Phytochemical and Pharmacological Profile of Anthriscus sylvestris as an Alternative Source for Anticancer Lignans. Molecules 2015, 20, 15003-15022.

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