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Molecules 2015, 20(8), 14293-14311; doi:10.3390/molecules200814293

The Stability, Sustained Release and Cellular Antioxidant Activity of Curcumin Nanoliposomes

State Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China
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Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 9 June 2015 / Revised: 18 July 2015 / Accepted: 22 July 2015 / Published: 5 August 2015
(This article belongs to the Section Natural Products)
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Abstract

Curcumin is a multifunctional and natural agent considered to be pharmacologically safe. However, its application in the food and medical industry is greatly limited by its poor water solubility, physicochemical instability and inadequate bioavailability. Nanoliposome encapsulation could significantly enhance the solubility and stability of curcumin. Curcumin nanoliposomes exhibited good physicochemical properties (entrapment efficiency = 57.1, particle size = 68.1 nm, polydispersity index = 0.246, and zeta potential = −3.16 mV). Compared with free curcumin, curcumin nanoliposomes exhibited good stability against alkaline pH and metal ions as well as good storage stability at 4 °C. Curcumin nanoliposomes also showed good sustained release properties. Compared with free curcumin, curcumin nanoliposomes presented an equal cellular antioxidant activity, which is mainly attributed to its lower cellular uptake as detected by fluorescence microscopy and flow cytometry. This study provide theoretical and practical guides for the further application of curcumin nanoliposomes. View Full-Text
Keywords: curcumin nanoliposomes; stability; sustained release; cellular antioxidant activity; cellular uptake curcumin nanoliposomes; stability; sustained release; cellular antioxidant activity; cellular uptake
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chen, X.; Zou, L.-Q.; Niu, J.; Liu, W.; Peng, S.-F.; Liu, C.-M. The Stability, Sustained Release and Cellular Antioxidant Activity of Curcumin Nanoliposomes. Molecules 2015, 20, 14293-14311.

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