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Molecules 2015, 20(8), 13725-13739; doi:10.3390/molecules200813725

Phenolic Compounds from the Roots of Rhodiola crenulata and Their Antioxidant and Inducing IFN-γ Production Activities

1
Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
2
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin 300457, China
3
Department of Pharmacy, School of Medicine, Shenzhen University, Shenzhen 518060, China
4
Shijiazhuang Yiling Pharmaceutical Co., Ltd, Shijiazhuang 050035, China
The authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editors: Luis Cisneros-Zevallos and Daniel Jacobo-Velazquez
Received: 30 June 2015 / Revised: 20 July 2015 / Accepted: 23 July 2015 / Published: 28 July 2015
(This article belongs to the Special Issue Recent Advances in Plant Phenolics)
View Full-Text   |   Download PDF [1032 KB, uploaded 28 July 2015]   |  

Abstract

In the present study, two new phenolic compounds 1 and 11, a pair of lignan isomers 12 and 13 with their absolute configurations established for the first time, were isolated from the ethanol extract of the roots of Rhodiola crenulata, together with 13 known phenolic compounds, and their structures were elucidated via NMR, HRESIMS, UV, IR and CD analyses. All the isolated compounds were evaluated for their in vitro antioxidant activities using the 2,2-diphenyl-1-picryhydrazyl (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assays. Ten of them exhibited significant antioxidant activities compared to ascorbic acid. Furthermore, the inducibilities of the isolated compounds to IFN-γ production were also assessed. Compounds 1, 8, 9, 12, 13, 14 and 15 could moderately stimulate IFN-γ expression. View Full-Text
Keywords: Rhodiola crenulata; phenol; antioxidant activity; IFN-γ production; immunomodulatory effect Rhodiola crenulata; phenol; antioxidant activity; IFN-γ production; immunomodulatory effect
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhou, J.-T.; Li, C.-Y.; Wang, C.-H.; Wang, Y.-F.; Wang, X.-D.; Wang, H.-T.; Zhu, Y.; Jiang, M.-M.; Gao, X.-M. Phenolic Compounds from the Roots of Rhodiola crenulata and Their Antioxidant and Inducing IFN-γ Production Activities. Molecules 2015, 20, 13725-13739.

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