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Molecules 2015, 20(8), 13670-13688; doi:10.3390/molecules200813670

Oleanolic Acid, a Compound Present in Grapes and Olives, Protects against Genotoxicity in Human Mammary Epithelial Cells

1
Immunology Division, Department of Health Sciences, Faculty of Experimental Sciences, University of Jaén, Campus las Lagunillas s/n, 23071 Jaén, Spain
2
Centro de Estudios Avanzados en Olivar y Aceites de Oliva, University of Jaén, Campus las Lagunillas s/n, 23071 Jaén, Spain
3
Agrifood Campus of International Excellence, ceiA3, University of Jaén, Campus las Lagunillas s/n, 23071 Jaén, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: David D. Kitts
Received: 26 June 2015 / Revised: 15 July 2015 / Accepted: 24 July 2015 / Published: 28 July 2015
(This article belongs to the Special Issue Antioxidants—A Risk-Benefit Analysis for Health)
View Full-Text   |   Download PDF [2653 KB, uploaded 28 July 2015]   |  

Abstract

Oleanolic acid (AO) and maslinic acid (MA) are constituents of the skins of different fruits, including olives and white or red grapes. Although both compounds are known to have beneficial properties against different types of cancers, thus far, there are no studies about their chemopreventive effects in human breast cancer. Thus, we sought to elucidate whether both compounds possess chemopreventive activity. Two cell lines of human breast cancer cells and one noncancerous human mammary epithelial cells were used to determine the effects of OA and MA. The results showed that OA inhibited the proliferation and increased the oxidative stress of highly invasive cells. Additionally, OA decreased oxidative stress and oxidative damage to the DNA in human mammary epithelial cells. These results suggest that OA could act as a chemopreventive agent in human breast cancer and could inhibit the proliferation of highly invasive breast cancer cells. View Full-Text
Keywords: virgin olive oil; wine; maslinic acid; MCF7; MDA-MB-231; MCF10A; chemopreventive; antitumoral virgin olive oil; wine; maslinic acid; MCF7; MDA-MB-231; MCF10A; chemopreventive; antitumoral
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sánchez-Quesada, C.; López-Biedma, A.; Gaforio, J.J. Oleanolic Acid, a Compound Present in Grapes and Olives, Protects against Genotoxicity in Human Mammary Epithelial Cells. Molecules 2015, 20, 13670-13688.

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