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Molecules 2015, 20(7), 13205-13215; doi:10.3390/molecules200713205

New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris

1
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, Taiwan
2
National Museum of Marine Biology & Aquarium, Pingtung 94450, Taiwan
3
Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan
4
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40447, Taiwan
5
Department of Neurosurgery, Xiamen Chang Gung Memorial Hospital, Xiamen 361028, China
6
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
7
Institute of Oceanography, National Taiwan University, Taipei 10617, Taiwan
8
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 40402, Taiwan
9
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
10
Center for Molecular Medicine, China Medical University Hospital, Taichung 40447, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editors: Derek J. McPhee and John Beutler
Received: 24 June 2015 / Revised: 15 July 2015 / Accepted: 17 July 2015 / Published: 21 July 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [875 KB, uploaded 21 July 2015]   |  

Abstract

Two new 15-hydroxycembranoid diterpenes, 2β-hydroxy-7β,8α-epoxynephthenol (1) and 2β-hydroxy-11α,12β-epoxynephthenol (2), were isolated from extracts of the octocoral Nephthea columnaris along with a new natural cembrane, epoxynephthenol (3) and a known sterol, nephalsterol A (4). The structures of cembranes 13 were elucidated by spectroscopic methods and comparison of the spectroscopic data with those of related analogues. The cytotoxicity of metabolites 14 against a panel of tumor cells is also described. View Full-Text
Keywords: Nephthea columnaris; octocoral; cembrane; nephalsterol; cytotoxicity Nephthea columnaris; octocoral; cembrane; nephalsterol; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hsiao, T.-H.; Cheng, C.-H.; Wu, T.-Y.; Lu, M.-C.; Chen, W.-F.; Wen, Z.-H.; Dai, C.-F.; Wu, Y.-C.; Sung, P.-J. New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris. Molecules 2015, 20, 13205-13215.

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